Endocrine Abstracts

Sixty-six patients with type 2 diabetes, obesity and no known history of cardiovascular disease were recruited to a lifestyle-intervention study. The aims of this study were to quantify the presence of silent and symptomatic ischaemia using a Bruce protocol treadmill-test, and to identify factors associated with a positive stress-test in these patients. Ethical approval was obtained from the local ethics committee.54/66 patients had blood pressure (BP) g...

Most aldosterone-producing adenomas (APAs) have gain-of-function somatic mutations of ion channels or transporters. However, their frequency in aldosterone-producing cell-clusters of normal adrenals could suggest the existence of co-driver mutations which influence the development or phenotype of APAs [1]. Gain-of-function mutations in both CTNNB1 and the G-protein coupled receptor GNA11 were found by whole exome sequencing in 3/10 APAs. Further sequencing of...